[Source: Research & Innovation] 
Challenges facing rural regions include few higher educational opportunities and lack of public transport, healthcare and shops. An EU-funded project combines research and training to help entrepreneurs improve life in such areas so as to encourage young people to stay and persuade those who have left to return.
William Grossman has been appointed chief medical officer of Bellicum Pharmaceuticals (NASDAQ: BLCM). Grossman comes to the Houston biotech company from Genentech, where he was group medical director, cancer immunotherapy. Bellicum develops immunotherapies for cancers and blood disorders. In January, the company disclosed that the FDA halted a clinical trial testing its lead drug, BPX-501, after three patients in the study developed brain injuries.
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An opinion column on AgWeek.com looks at the promises of gene editing and the questions that still remain about the regulation and acceptance of such technologies.
Those two factors could determine whether the United States will nurture the potential for breakthroughs in the areas of human health, animal health and food production or lag behind other countries who are eager to harness gene editing’s potential.
Sara Wyant, president and founder of Agri-Pulse Communications Inc. authors this piece with contribution from Agri-Pulse’s Ed Maixner:
The process of producing better food, protecting the environment and improving animal health is advancing at a seemingly breakneck pace.
These advancements are driven in part by new scientific discoveries, genetic research, data science, enhanced computational power and the availability of new systems for precision breeding like CRISPR – an acronym for Clustered Regularly Interspaced Short Palindromic Repeats.
“We use the term ‘gene editing’ rather loosely” in the world of science, said Bernice Slutsky, senior vice president for the American Seed Trade Association. At its core, gene editing is “plant breeding innovation,” she said. “Plant breeders have always used a range of tools – a toolbox of different disciplines.”
With the new techniques, they are “doing the same things that breeders have always done, but very precisely,” she said.
The outcomes possible with different types of gene editing today might have seemed impossible just a few decades ago. And now, these new opportunities have strong implications for both producers of crops and livestock, as well as consumers. Consider just a few of the possibilities:
Indeed, the science is moving so rapidly that some are wondering if producers, consumers and regulators will ultimately be able to understand and embrace the changes.
As history demonstrates, new advancements in breeding have almost always been controversial – even though safety or environmental risks have not been proven.
It’s important to always remember that, “science and innovation always outruns law and policy. These ethical and moral questions are not new,” said Bill Even, CEO of the National Pork Board who also owns a farm in South Dakota. “They arise every time a new technology emerges.”
“I would have these same discussions when I worked at Pioneer,” Even recalls about some of the Iowa-based seed company’s early research aimed at improving corn yields. “When Henry Wallace pioneered the use of hybrid seed corn in the 1920s, there were all sorts of people saying, ‘the sky is falling,’ ‘you’re messing with God,’ and this is ‘not the natural way things should happen.’ There was all this fear mongering. Now, it’s viewed as one of the most successful improvements in agriculture and modern history. And people assume it’s natural and they welcome it.”
Kevin Folta, who chairs the Horticultural Sciences Department at the University of Florida in Gainesville, agrees.
“It is critically important that everyone in agriculture becomes rapidly conversant in this technology, as it already has been a game changer,” he notes “If these technologies are delayed because of misunderstanding, we will lose many opportunities to bring improved varieties to the field and better fruits and vegetables to consumers.”
One important thing to keep in mind: These new gene-editing tools are much different than genetically modified organisms or GMOs, that activist groups have given such a bad rap.
“We’re very excited by the potential for gene editing, and not only against PRRS … a devastating disease to the industry,” says veterinarian Dan Kovich, speaking for the National Pork Producers Council.
“In the future, looking to other applications for disease resistance, prevention, management – all sorts of traits – I think the potential is there (for gene editing) traits that can have an impact on animal welfare, reducing need for antibiotics,” he says. “This is very different from the (genetically modified organisms) that people have talked about in the past.”
With gene editing, no genes from foreign species are introduced.
“I think there are very sound reasons why the marketplace will be accepting of this technology. This is a very precise technology, working within the genome of the pig. It’s not transgenics,” he says. So, he says, NPPC is “just really excited about where this can go.”
Gene editing is akin to cutting and pasting text within a document, explained Jennifer Doudna, professor of molecular and cell biology and chemistry at the University of California, Berkeley, at a recent conference on gene editing.
In the 25 years of her cell biology and biochemistry career, she has “never seen science moving at the pace it is moving right now,” and she sees gene editing as generating much of the stampede.
Nevertheless, gene editing will have to jump huge policy hurdles – both domestically and internationally – before results of such plant and animal breeding show up on farms, in fields and in food stores.
Plant breeders must currently seek regulatory approval from the U.S. Department of Agriculture. Animal breeders must seek approval from the Food and Drug Administration, which requires new animal varieties to be tested as a “drug.” They are watching carefully to see how new regulations evolve and ultimately, how consumers accept these new products of precision breeding.
At the same time, a number of scientists, consumer and food safety advocates want to see the U.S. and world governments lump gene editing in with transgenic genetic alterations and regulate it as just another type of genetically modified organism. That would almost surely ensure years of testing and approval for each product – dramatically running up the costs to produce these innovative new gene-edited products commercially.
[Source: http://ec.europa.eu/health/ageing/innovation/index_en.htm] Identifier: REC-AG-2017Pillar: REC Programme 2014-2020Opening Date: Deadline: Thu, 29 Jun 2017 17:00:00 (Brussels local time)Modification Date: Thu, 8 Feb 2018Latest information: A Questions and answers document has been added under Topic conditions, Additional documents.
Teva Pharmaceutical’s bid to bring a new migraine drug to the market faces a possible delay due to manufacturing problems found with one of the company’s partners, and observers are skeptical about whether Teva will be able to get it over the finish line.
The FDA was set to issue a decision about Teva’s (NYSE: TEVA) injectable migraine drug, fremanezumab, by June 16. But the Israel-based drug maker disclosed Thursday that Celltrion, the manufacturer of the active ingredient for the drug, received an FDA warning letter about unspecified issues at a site in South Korea where it makes the drug… Read more »
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Victor Tangermann writes for Futurism on myths and misconceptions about the food we chose to eat every day. Do foods labeled “organic” actually make us healthier? Are they free of pesticides? Should we be afraid of pesticides in the first place? What about GMOs?
Many studies have shown that just because a food is labeled “organic,” that doesn’t mean it was grown without pesticides (more on that later). In any case, scientists note that limiting the consumption of fruits and vegetables for fear of pesticide use could be much worse for consumers’ health than inadvertently consuming a little bit of pesticide.
“My biggest concern is that a lot of these reports may [produce] a negative effect in that they may discourage people from consuming what are perfectly healthy, conventionally-produced [non-organic] fruits and vegetables,” Carl Winter, food toxicologist at the University of California, Davis and member of the Institute of Food Technologists, told Futurism. “While everybody wants to do what they hear is the right thing, they could be doing themselves more harm than good in the long term.”
Here are four common, pervasive myths about GMOs and organic foods. Understanding what the science says can help consumers ensure that they choose the food that will best keep them healthy:
Myth 1: Organic Food Is Safer Because It Doesn’t Touch Pesticides
Organic foods, by definition, can’t have had synthetic fertilizers or pesticides applied to them for three years before they are harvested. But just because a crop fits the definition of organic doesn’t mean it’s totally free of pesticides or fertilizer residue.
USDA organic certification allows for natural substances such as pheromones, vaccines for animals, and a limited number of natural pesticides as well. A 2005 market trends survey by Whole Foods found that more than 70 percent of consumers bought organic food to avoid pesticides.
Myth 2: Organic Food Is Healthier
Since the U.S. government began regulating organic products in 1990, proponents have claimed that eating organic food makes us healthier. That claim, as difficult as it is to nail down, is ultimately misleading.
After analyzing 240 studies about the nutritional value of organic food, the authors of a 2012 review study published in the Annals of Internal Medicine concluded that they “[lack] strong evidence that organic foods are significantly more nutritious than conventional foods.”
Myth 3: GMOs Are Dangerous to Eat
There is no trustworthy evidence that any GMO-derived food poses health risks to humans. If anything, genetic modifications make crops safer for agricultural workers (genetic tweaks make crops more resistant to damage from insects and viral infections, so plants need fewer pesticides) and even make them more nutritious, bringing a healthful variety to more people worldwide. According to the WHO, no foods available today based on genetically modified crops have been shown to have a negative effect on human health in the countries in which they have been approved.
Myth 4: GMOs Are Bad for the Environment
A 2016 study found that GMOs actually reduced the amount of pesticides needed to raise the same amount of maize compared to crops that didn’t use GM strains of maize engineered to resist pests. Another 2014 study found that genetically modified crops had a 22 percent greater yield than non-GM varieties. More food per square meter could mean that less land is needed worldwide for agriculture, leaving more habitats undisturbed or allocating more land for natural reserves or wildlife corridors. Plus, many GMO crops need less water than organic or non-GM varieties, which will help feed everyone in a warmer world.
Scientists are still not completely sure if GMOs are better for the environment than other types of crops. But they at least demand fewer resources than organic crops.
At the end of the day, “organic” food isn’t a bad option. And neither are GMOs. But consumers should make their food choices based on science, not hearsay. Many myths persist around the risks of GMOs and the benefits of organic foods. But one thing is clear: eating fruits and vegetables is the most important thing, no matter if they’re organic or GMO.
Patients treated with an experimental Amicus Therapeutics drug for Pompe disease continued to show improvement in their ability to walk, move, and breathe after as long as one year on the therapy, according to the latest clinical trial results from the rare disease drug developer.
The open-label study is small, testing the drug in just 20 patients. But the latest results build on interim data that the company released last October assessing patients at the six- and nine-month marks. Cranbury, NJ-based Amicus (NASDAQ: FOLD) is scheduled to present the latest results Thursday in San Diego at the WORLDSymposium, an annual… Read more »
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[Source: http://ec.europa.eu/health/ageing/innovation/index_en.htm] Identifier: H2020-LC-CLA-2018-2019-2020Pillar: Societal ChallengesPlanned Opening Date: Deadline: Tue, 18 Feb 2020 17:00:00 (Brussels local time)Modification Date: Wed, 7 Feb 2018Latest information: The page limit for a first stage proposal is 10 pages, including the cover page. You may remove the page break in that page so as to start drafting your proposal therein.
Everyday it’s a new headline. The numbers keep rising. No, we’re not talking about the latest lottery jackpot. We’re talking about one of the worst flu seasons in nearly 10 years. But it’s not too late to protect yourself with a flu vaccine – and here’s why you should:
“The negatives of a flu shot are almost nonexistent, and significant side effects are very rare. Even in an ineffective year, the benefits greatly outweigh the harms. The [CDC] estimates that 9 million to 36 million people become ill with the flu each year in the United States. Somewhere between 140,000 and 710,000 of them require hospitalization, and 12,000 to 56,000 die each year,” the New York Times reports.
This messy flu season is not only impacting individuals and families, though. Businesses across the nation can expect to see billions of dollars in lost productivity as a result of employees falling ill. One recent estimate predicted that 11 million Americans will fall ill this season, at a cost to their employers of over $9 billion in sick leave.
As we’ve pointed out before, vaccines have tremendous societal value, responsible for saving more than 730,000 children over the past 20 years in the U.S. Another study found that the vaccination of children born in the United States in 2009 is projected to generate $184 billion in lifetime social value – or about $45,000 per child.
If you’re still not convinced, data from the CDC confirms the benefits of getting a flu shot. In fact, it’s estimated that number of flu hospitalizations prevented by vaccination during the 2015-2016 season was more than 70,000, while over 5 million cases of illness were prevented. And if you’re wondering how widespread influenza is in your state or region of the country, check out this map for details.
While every flu season is slightly different, getting vaccinated is still the best way to prevent a few sick days on the couch or a trip to the hospital. As flu season continues on its path of destruction, help protect yourself and those around you by getting vaccinated.
