13 Sep

Bloomberg Exposes How Drug Cost Middlemen “Rake in Millions”

Bloomberg has authored an investigative piece exposing drug cost middlemen, better known as pharmacy benefit managers (PBMs), for their role in marking up prices for common drugs and pocketing the difference.

At issue is a little-known tactic called “spread pricing”, a strategy designed to pad the pockets of PBMs at the expense of the client, who in this particular case were Iowa taxpayers funding the state’s Medicaid program. As pharmacist Mark Frahm learned firsthand, what one PBM charged the pharmacy, and what the PBM then billed the state for a common prescription differed dramatically.

“For years, Frahm’s South Side Drug bought pills from distributors, and dispensed prescriptions to the Wapello County jail. In turn, the pharmacy got reimbursed for the drugs by CVS Health Corp., which managed the county’s drug benefits plan.

“As he compared the newspaper notice with his own records, and then with the county’s, Frahm saw that for a bottle of generic antipsychotic pills, CVS had billed Wapello County $198.22. But South Side Drug was reimbursed just $5.73.”

So where did the $192.00 difference go? To the bottom line of the middlemen.

“’Middlemen have to make some money, but we didn’t expect it to be this extreme,’ said Frahm, who said his pharmacy lost money in the jail account last year because CVS paid so little. ‘We figured everyone was playing fair.’”

Frahm’s case, however, is not isolated. Bloomberg analyzed the data of PBM markups in Medicaid plans around the country, finding massive spreads on dozens of drugs. For example, of “the 90 drugs analyzed, which includes more than 500 dosages and formulations, PBMs and pharmacies siphoned off $1.3 billion of the $4.2 billion Medicaid insurers spent on the drugs in 2017.”

But middlemen working behind the scenes to protect their profit margins is nothing new. In a state-commissioned report, Ohio officials found that PBMs billed taxpayers roughly $220 million more for prescription drugs than they reimbursed pharmacies to fill those prescriptions over the course of a year.

Source: Bloomberg News

Similarly, private Medicaid plans in Indiana spent more than $800 for a 30-day supply of a hepatitis B pill that cost pharmacies less than $140 to buy.

Source: Bloomberg News

As we explain in our “Follow the Pill” video, the drug cost ecosystem is more complex than most people think. Insurers and PBMs largely decide how much people pay out of pocket for the medicines they need. As Bloomberg and others have shown, the decisions these middlemen make can have costly consequences for both patients and taxpayers.

Read the full Bloomberg story here, and learn more about how the drug cost ecosystem works here.

12 Sep

Gilead Partners with Precision Bio in Search of Gene-Editing HBV Cure

Gilead Sciences is turning to gene editing in its effort to develop a cure for hepatitis B virus infections-DNA-cutting enzymes that would eliminate the virus in the body, something current hep B drugs can’t do.

Foster City, CA-based Gilead (NASDAQ: GILD) is partnering with Precision Biosciences, a company that has used its proprietary gene-editing platform to develop products for both agriculture and human health. No upfront payments were disclosed, but if the alliance results in commercialized drugs, Durham, NC-based Precision stands to gain up to $445 million in milestone payments and royalties. Under the agreement, Gilead will fund the research… Read more »

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12 Sep

Nebraska City plans Twitter town hall

Nebraska City’s City Council, Mayor Bryan Bequette and other officials will participate in the city’s first-ever Twitter town hall meeting Thursday evening …

12 Sep

Call for proposals for ERC Proof of Concept Grant

[Source: http://ec.europa.eu/health/ageing/innovation/index_en.htm] Identifier: ERC-2018-PoCPillar: Excellent ScienceOpening Date: Deadline: Tue, 11 Sep 2018 17:00:00 (Brussels local time)Modification Date: Wed, 12 Sep 2018Latest information:

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A total of 190 proposals were submitted in response to the third and final deadline (11 September 2018) of this ERC 2018 Proof of Concept call (ERC-2018-PoC).

11 Sep

Andrew Cheng Departs Gilead Sciences for Akero Therapeutics CEO Post

Andrew Cheng has been appointed president and CEO of Cambridge, MA-based Akero Therapeutics. Cheng comes to Akero following a nearly 20-year career at Foster City, CA-based Gilead Sciences (NASDAQ: GILD), where he was most recently chief medical officer and executive vice president. Cheng will be based in San Francisco, which will be the location for Akero’s new headquarters. With Cheng’s appointment, Akero’s co-founder and former CEO Jonathan Young shifts to executive vice president and chief operating officer. Akero launched in June backed by $65 million in Series A financing. Lead drug AKR-001, an experimental treatment for nonalcoholic steatohepatitis that… Read more »

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11 Sep

Research Headlines – Shaping the future of Europe’s energy policy

[Source: Research & Innovation] The transition toward clean, efficient and secure energy will require more than just technological innovation. An EU-funded project is applying research insights from across the social sciences and humanities to help guide European energy policy.

11 Sep

Greenwood Highlights Role of Innovation in Solving Opioid Crisis

The numbers are staggering. The opioid epidemic is costing our nation more than $500 billion annually in health and social costs. What’s more, 1 in 5 deaths among young adults in 2016 were opioid related. This crisis is plaguing communities across the country, leaving in its wake countless victims, devastated families and economic ruin.

Jim Greenwood, BIO’s President and CEO, has been on the air describing for radio listeners across the country the urgent need to spur access to, and greater innovation of, novel therapies to help treat both pain and addiction.

Don’t miss Jim’s recent radio interviews:

And for more information about the biopharmaceutical industry’s commitment to combating the opioid crisis, please visit www.bio.org/opioid.

11 Sep

OncoResponse Nabs $40M for Cancer Drugs Based On Survivors’ Antibodies

Houston-OncoResponse, a Seattle biotech startup formed jointly with the University of Texas M.D. Anderson Cancer Center in Houston, announced Tuesday it has raised a $40 million Series B round of funding.

RiverVest Venture Partners led the round, which included new investors Redmile Group and the Qatar Investment Authority, as well as existing investors Alexandria Venture Investments, ARCH Venture Partners, HT Family Office, Canaan Partners, Helsinn Investment Fund, and Rice University. The company had previously closed on a $22.5 million Series A round of funding last year.

The funding will be used to advance five different therapy programs based on antibodies… Read more »

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10 Sep

Sustainable and circular Bioeconomy, the European way – 22 October 2018, Brussels, Belgium

[Source: Research & Innovation] The emerging bioeconomy is moving from research niche to market norm and Europe needs to maintain its current global leadership.
The conference will focus on the need to have a sustainable and circular bioeconomy to enhance the transition in a changed EU policy context and towards a new environmental, social and economic reality. It will also set the scene for the start of the discussion about synergetic actions across different priority areas:

• support strategic research and innovation, and strengthen support for education and training,
• upscale the bio-based sectors, mobilise investments, support the creation of markets, develop better monitoring,
• encourage the adoption, update and coherence of national and regional Bioeconomy Strategies throughout Europe with citizens engagement,
• strengthen the understanding and resilience of land and sea ecosystems,
• monitoring and assessment of bioeconomy development

Registration is now open.
Registration is on “first come first served” basis. Please register by 17 October 2018.
Venue: Charlemagne building, Brussels

10 Sep

The Patient Perspective-Valuable for Drug Development

Congress, the Food and Drug Administration (FDA), drug developers, researchers and patient groups have all recognized the contribution patients and caregivers can make to the drug development process. Since 2012, the FDA has incorporated the patient’s voice in disease-specific “patient-focused drug development” (PFDD) meetings to help inform the regulatory drug approval process. Who better to tell the story of how a disease manifests, or what they are experiencing on a daily basis or what side-effects are emerging from certain treatments.

Just as regulators and drug developers need and want to hear from patients, the patients, themselves, are anxious to hear about the latest developments and policies that can impact their lives. By staying informed on the latest policies, and by engaging across stakeholder groups, patient advocacy organizations serve as the voice of patients they represent, ensuring access to care and support for the pathways to effective treatment.

This October, BIO invites patient advocacy organizations to engage with the entire array of stakeholders in the drug development journey, from regulators to researchers to biopharma companies. The Patient and Health Advocacy Summit will run October 25 – 26 at the Park Hyatt hotel in Washington, DC.  During the two-day Summit, attendees can meet with other groups to learn best practices and hear from expert panelists on patient access and affordability and ways to support the discovery of new and safer treatments for pain and addiction.

This is the seventh year BIO is hosting the summit. Dean Suhr, President of the MLD Foundation has attended in the past and had this to say about the event: “The BIO Patient & Health Advocacy Summit is a very powerful intersection of pharma, biotech, and advocacy. The exchange of challenges, ideas, concerns, and opportunities at this BIO conferences is a very powerful force in refining the perspectives, thinking, and impacting future plans of those attending. The setting is modest in size allowing not just for superficial networking, rather there is time and space for in depth conversation and follow-up.”

Enhancing conference networking is BIO One-on-One Partnering™.-a unique and efficient way to schedule individual meetings with other attendees. The versatile program allows users to create profiles and send meeting requests. When the meeting is accepted, the program schedules the meeting.

Registration for the BIO Patient and Health Advocacy Summit is open.

The event is made possible through the generous contributions of our sponsors.

 

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Sponsors as of September 6, 2018